Fibroadenois etiology

 

Q. 12: What changes do happen after the period is over and hormonal level decreases?? Ans: When the monthly cycle is over, these stimulated breast cells cannot simply slough away and pass out of the body like endometrium . Instead, many of these breast cells undergo a process of programed cell death, called apoptosis. During apoptosis, enzymes are activated that start digesting cells from within. These cells break down and the resulting cellular fragments are then further broken down by scavenger cells (inflammatory cells) and nearby glandular cells.

What changes do happen after the period is over and hormonal level decreases (contd) ?? During this process, the fragments of broken cells and the inflammation may lead to scarring (fibrosis) that damages the ducts and the clusters (lobules) of glandular tissue within the breast. The inflammatory cells and some of the breakdown fragments may release hormone-like substances that in turn act on the nearby glandular, ductal, and structural support cells.

The amount of cellular breakdown products, the degree of inflammation, and the efficiency of the cellular cleanup process in the breast vary from woman to woman. These factors may also fluctuate from month to month in an individual woman. They may even vary in different areas of the same breast.

Q. 12 Dietary modifications: At this time, there is a great deal of circumstantial evidence that dietary and hormonal factors can affect fibrocystic breast condition. Avoidance of caffeine is a good idea , still, a firm association between dietary factors and fibrocystic breast condition has not been established.