Q.1: Can persistent still unrecognized Hyper Homocysteinaemia
be a cause of unexplained subfertility? Or
to put in other way round , should we routinely estimate Homocysteine in
subfertile men and also in women where no definite cause is located? Ans:
Unexplained subfertility is a condition where both treating doctor & couple are frustrated. But fact
remains that Homocysteine is an important
adverse molecule both in genital organs,
reproductive potential and also in
metabolic events too. It acts like ROS. AS such its measurement of H.cy becomes relevant in above mentioned clinical set
up.
Homocysteine has been identified as an independent
risk factor for A) atherosclerosis (As) and B) birth defective disease.
Different .
Epidemiological
studies have evaluated the association between MTHFR 677C>T and 1298A>C polymorphisms and risk of C)
male infertility.. The
MTHFR 677T allele might be a low-penetrant risk factor for male infertility,
especially in Asian population.
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