What is the Physiology of homocyteine
? :-How does it act in the body??
Mode of action:- Hcy
It
causes transfer of activated methyl
group from tetra-hydrofolate to S-adenyl-methionine.(It ,therefore plays a
significant role in the synthesis of cyteine from methionine. In this pathwayàthere is therefore production of Homocyteine thiolactone. In hyperhomocyteimia
there can be abnormal rise of plasma / urinary Homocyteine. What may the
known causes of abnormal rise of
Homocyteine: There is considerable ethnic variation on HHcy. Therefore
there are -genetic, inflammatory, demographic, ethnic, nutritional, or most
importantly an effect of metabolic disorders.
3)
What is normal level? Normally the
serum level should be less than
10 mmol/L but preferably at about 5 mmol/L.
5) What are the ill
effects of excess homocyeine? Homocyteine, its high level can lead to 1) arterial
endothelial more preferentially damageà first documented plasma lipopopotein alpha-A, -à then thrombosis & Atherosclerosis. Mild elevation can lead to
premature vascular diseases, àdiastolic dysfunction which is a surrogate marker of Early marker of
diastolic dysfunction.
2) In
young PCOS with hyperhomocyteimia- there be associated rise of uric acid,
plasma insulin.
3) Atherosclerosis.
4) Formation of IR. à But regular physical exercise can minimize the IR & WHR.
5) In young PCOSà THERE IS SIGNIFCANT CORRELATION WITH H.Hcy & WHP
.
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