Hormonal requirement of spermatogenesis:- Take home message : FSH is said to maintain spermatogenesis. in a quantitative fashion by increasing spermatogoneal mitosis while testosterone is essential for steps in meiosis and spermiogenesis. Normal spermatogenesis requires action of both pituitary gonadotropins – LH and FSH. This is the rule at least at the onset of puberty.
A) LH stimulates Leydig cells, which produce testosterone. B) FSH initiates
function in immature Sertoli cells even before the beginning of
spermatogenesis. This helps in producing a blood/testis barrier and secretion
of tubular fluid and other products required for spermatogenesis.
B)
Once spermatogenesis is established, Sertoli cells function independent
of FSH.
C)
In view of this, the contributions made by the
two gonadotropins in maintaining spermatogenesis in adults are probably
superfluous.
Normal spermatogenesis is totally dependent on the local source of
testosterone produced by the Leydig cells of the testis. The concentration of
testosterone in testis is at least 25 to 50 times responsible for total testosterone
production, but in hypogonadotrophic
population may fall.
But in men with hypogonadotrophism, medical treatment consists of giving
both LH and FSH to enhance spermatogenesis. FSH alone
is ineffective without testosterone and for production of testosterone LH(hCG)
is necessary.
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