Azospermia Testicular

 

            TESTICULAR ASOOSPERMIA

The causes of testicular azoospermia are several. It is seen in A) Trisomy 21, B)  Klinefelter’s syndrome C) Chromosomal translocation, D) Orchitis  produced by infections like mumps, E) cryptorchidism, F)  Primary germ cells  aplasia (like ovarian dysgenesis )  , G) Sterol cell only syndrome, H) autoimmune phenomenon, environmental factors (heat, radiation, drugs, etc). It is been found that a gene controlling spermatogenesis is located in the human in the long arm of the Y chromosome. Many cases of azoospermia are related to various types of gene deletions on the Y chromosome. A gene known as azoospermia factor (AZF) has been identified in the DNA sequences of the human Y chromosome. The DNA sequences of the region containing AZF on the Y chromosome are likely to be identified soon and when this occurs the AZF gene can be therapeutically cloned.