Recurrent Pregancy Losses -Investigations

 

Tests for Recurrent Pregancy Loss (RPL) :-Type  A) Tests limited to  cavitary disorders of uterus :  transvaginal

Sonography, or saline contrast hystero sonography or

 Hysterosalpingography, any one is useful tools for detecting endometrial irregularity. However, hysteroscopy showed to be more accurate in the evaluation of intracavity pathology in comparison with any other study.

This kind of hysteroscopy is also useful of uterine reassessment by hysteroscopy in women with IVF failures.

 Type B tests :-- Systemic contribution factors such as thrombophilia, taking history, physical exam, routine hematological, Biochemical, hormonal tests, spermiogram, also

Flow cytometry, autoantibodies profile like anti-

Cardiolipin (aCL), Lupus Anticoagulant (LA), anti-

Phosphatidylserine (aPS), anti-phosphatidyl ethanolamine

(aPE), antinuclear antibodies (ANA), anti DNA, and

Thrombophilia include tests  like A) methylenetetrahydrofolate

reductase (MTHFR) gene-B) prothrombin gene, C) factor

V leiden gene,  D)  serum homocysteine ,E)  protein C, F) Protein

S, G) anti-thrombin III, and H)  karyotype have to be accomplished in all women with recurrent pregancy failure .

 and immunological disorders.