Hyper Homocytenaemia

 

Hyper Homocysteinaemia: What this protein does in body ?? What is the physiology & -Mode of action: - Homocysteine causes transfer of activated methyl group from tetra-hydrofolate to S-adenyl-methionine. (It therefore plays a significant role in the synthesis of cyteine from methionine. In this pathwayàthere is therefore production of Homocyteine thiolactone. In hyperhomocyteimia there can be abnormal rise of plasma / urinary Homocyteine.

What are the definite & presumptive causes of abnormal rise of Homocyteine: There is considerable ethnic variation on HHcst. Therefore there are -genetic, inflammatory, demographic, ethnic, nutritional, or most importantly an effect of metabolic disorders.

3)                   What is normal level? Normally the serum level should be less than 10 mmol/L but preferably at about 5 mmol/L.

5) What are the ill effects? Homocyteine, its high level can lead to 1) arterial endothelial more preferentially damageà first documented plasma lipopopotein alpha-A, -à then thrombosis & Atherosclerosis. Mild elevation can lead to premature vascular diseases, àdiastolic dysfunction which is a surrogate marker of early marker of diastolic dysfunction.

  2) What about in PCOS, particularly young PCO ?? In young PCOS with hyperhomocyteimia- there be associated rise of uric acid, plasma insulin. Atherosclerosis.

4) Formation of IR. à But regular physical exercise can minimize the IR & WHR.

 5) In young PCOSà there is significant correlation with Hhcy & WHP(Waist Hip Ratio) .