APC Resistance : Increased APC resistance can invite thrombosis

 

Lack of a response to activated protein C (APC), Acquired APC resistance:-  APC resistance :- APC resistance is characterized by a reduced anticoagulant response of patient.  Activated protein C resistance (APCR) is  hypercoagulability (an increased tendency of the blood to clot) characterized by a lack of a response to activated protein C (APC), which normally helps prevent blood from clotting excessively. This results in an increased risk of venous thrombosis (blood clots in veins), which resulting in medical conditions such as deep vein thrombosis (usually in the leg) and pulmonary embolism . APC naturally down regulates the thrombin formation. APC therefore is a naturally occurring  anticoagulant and if resistance is there there will be tendency to clot formation .  In acquired APC resistance the prevalence of  spontaneous DVT is 6/10,000 women in reproductive years(without OCP) . But if one uses OCP then the prevalence f DVT goes up-