Oestrogens & VTE:-- Estrogen cause slight increase in fibrinogen and by that promotes
slightly increased prevalence of venous thrombosis in prolonged use . But this is peculiar for EE
(Ethinyl oestradiol) which is a very
potent oestrogen Though 20 mcg EE containg Pill (Loette) / 15 mcg(Minesse) and even 10 mcg have been used still some amount
of risk remains. That is why many women are switching over to COC with natural orstrogens
which will regularize the cycle with no added risk of VTE . I have mentioned
many a times on CC with natural oestrogens
.
Of the contraceptive steroids we
should remember that it is the estrogen which causes hypercoagulable state and
is primarily attributed for DVT and allied thrombosis during OCP intake. The
risk of VTE is directly related to dose of E but the OCP induced risk of VTE in pregnancy is lower than the risk associated
with even low-dose coc.
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