Genetic alterations in the biosynthesis of androgens in PCO teenagers and young PCO subfertile in particular . What is exaggerated adrenarche?? What happens at Adrenal & ovarian theca cells about androgen production> Which enzyme undergo wild. mad??/
A) At ovary:-•Rosenfield proved that a hyperactivity of cytochrome P450cl7α ,
•This enzymatic complex binds progesterone and converts it sequentially in 17-hydroxyprogesterone (via a 17α -hydroxylation) and androstenedione (via a C-17, 20-lytic activity).
B) What ahhapens at adrenals?? The steroidogenetic route particularly involved in the ovary in the A-4 pathway.-•Cytochrome P450c17α forms 17-ketosteroids, especially using the A-5 steroidogenetic pathway, and it creates more dehydroepiandrosterone than androstenedione.
An abnormal regulation of this enzyme activity, therefore, both at ovarian and adrenal levels, could explain the androgenic hyper function of both glands, as occurs in PCO
No comments:
Post a Comment